![]() The high capacity tray also enables completely automated sampling for all tests, including osmometry, for automated culture systems such as the Sartorius ambr®15. Total cell density, viability, cell diameterĪnalysis time and sample size when all modules are run collectivelyįLEX2’s high capacity, 48-position osmometer enables walkaway, automated sampling of up to 48 samples without any user intervention, significantly prolonging maintenance intervals. Gluc, Lac, Gln, Glu, NH 4 +, Na +, K +, Ca + + Individual modules require as little as 135 μL.Īnalysis time and sample size when modules are run individually Sample volume is 275 μL for a full 16-test profile, enabling comprehensive testing even from low volume culture systems. Throughput for individual modules is 2.0 minutes. Other systems can pose significant waste handling hazards to operators.Ĭomprehensive test results including cell density/viability, pH/gases, and key chemistries are available in 4.5 minutes. A self-contained waste receptacle within the cartridge eliminates direct handling of waste and direct contact with hazardous trypan blue and biological materials.RMS monitors reagent usage and provides real-time reagent status and alerts, maximizing analyzer readiness.RMS automatically captures cartridge installation date and time, lot number, and expiration.MicroSensor Cards are maintenance-free, and replaceable in seconds.Ĭartridge-based reagent management system (RMS)įLEX2’s RMS features smart reagent cartridges that are easy to use with simple snap-in replacement. ![]() The OLS can connect up to 10 vessels and setup time for a full bench of 10-bioreactors can be completed in less than 20 minutes.Ĭhemistry and gas biosensors are combined in credit-card-sized MicroSensor cards, which use proven Nova biosensor technology that has been validated in thousands of cell culture processes. When connected to an OPC-compatible control system, FLEX2 wih OLS provides real-time data transmission for automated sampling, analysis, and feedback control of all measured parameters. Nova’s FLEX2 On-Line Autosampler (OLS) providesįully automated sampling from virtually all culture systems from single-use bench scale bioreactors to large production bioreactors. ![]() Automated sampling from 96-well plates, syringes, or a 24-position external “load-and-go” sample tray provides maximum workflow flexibility and efficiency for cell culture monitoring.įully Automated Sampling Options FLEX2 Online AutosamplerīioProfile FLEX2 is capable of automated online sampling. The full 16 cell culture test menu includes: Gluc, Lac, Gln, Glu, NH 4 +, Na +, K +, Ca + +, pH, PCO 2, PO 2, total cell density, viable cell density, viability, cell diameter, and osmolality.Ĭompared to the previous generation BioProfile FLEX there is no maintenance for any of the 11 chemistry and gas sensors, sample volume for the full test menu is reduced by 75% to 275 microliters, and testing time is reduced to just 4.5 minutes. BioProfile ® FLEX2 Automated Cell Culture Analyzer with Maintenance-Free Chemistry SensorsīioProfile FLEX2 combines Nova’s groundbreaking MicroSensor ™ Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. ![]()
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